Cetrizine tablets| Cetrizine dihydrochloride tablets
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| Cetrizine tablets |
Cetirizine tablets- Cetrizine tablet is a metabolite of hydroxyzine with a marked affinity for peripheral H1 receptors; penetrates the brain poorly, but mild sedation and subjective somnolence are experienced by many recipients. It is not metabolized; does not prolong cardiac action potential or produce arrhythmias when given with erythromycin/ketoconazole.
Cetirizine tablets besides inhibit the release of histamine and of cytotoxic mediators from platelets as well as eosinophil chemotaxis during the second phase of the allergic response. Thus, it may benefit allergic disorders by other actions as well. It attains high and longer-lasting concentration in the skin, which may be responsible for superior efficacy in urticaria/atopic dermatitis, as well as for once-daily dosing despite elimination t½ of 7–10 hr. It is indicated in upper respiratory allergies, pollinosis, urticaria, and atopic dermatitis; also used as an adjuvant in seasonal asthma.
Cetirizine Uses- What is cetirizine used for?
The uses of H1 antihistaminics are based on their ability to block certain effects of histamine released endogenously, as well as on sedative and anticholinergic properties.
1. Allergic disorders Antihistaminics do not suppress AG: AB reaction, but block the effects of released histamine—are only palliative. They effectively control the certain immediate types of allergies, e.g. itching, urticaria, seasonal hay fever, allergic conjunctivitis and angioedema of lips, eyelids, etc. However, their action is slow—ADR alone is life-saving in laryngeal angioedema, though intravenously administered antihistaminic may have adjuvant value. Similarly, they cannot be relied upon in anaphylactic shock and have a secondary place to ADR. Benefits are less marked in perennial vasomotor rhinitis, atopic dermatitis, and chronic urticarias; combination with an H2 antagonist succeeds in some cases of chronic urticaria not responding to H1 antagonist alone.
The antihistaminics are ineffective in bronchial asthma: reasons maybe—
(i) Leukotrienes (C4, D4) and PAF are more important mediators than histamine.
(ii) Concentration of antihistamines attained at the site may not be sufficient to block a high concentration of histamine released locally in the bronchi. Certain newer compounds like cetirizine have an adjuvant role in seasonal asthma. Antihistaminics are also ineffective in other types of humoral and cell-mediated allergies because histamine is not involved. They do suppress urticaria and swellings in serum sickness but have no effect on other components of the syndrome. Type I hypersensitivity reactions to drugs (except asthma and anaphylaxis) are suppressed. Some skin rashes also respond.
2. Other conditions involving histamine Antihistaminics block symptoms produced by histamine liberators; afford symptomatic relief in insect bite and ivy poisoning. Abnormal dermographism is suppressed. They have prophylactic value in blood/saline infusion induced rigor.
3. Pruritides Many conventional antihistamines have antipruritic action independent of H1 antagonism. Though relief is often incomplete, older antihistaminics chlorpheniramine, diphenhydramine, cyproheptadine remain the first choice drugs for idiopathic pruritus.
4. Common cold Antihistaminics do not affect the course of the illness but may afford symptomatic relief by anticholinergic (reduce rhinorrhoea) and sedative actions. The newer nonsedating antihistamines are less effective in
this respect.
5. Motion sickness Promethazine, diphenhydramine, dimenhydrinate, and meclozine have prophylactic value in milder types of motion sickness; should be taken one hour before starting the journey. Promethazine can also be used in morning sickness, drug-induced and postoperative vomiting, radiation sickness. An ‘off label’ (unapproved) use of cyproheptadine is often made in anorectic/convalescent patients for improving appetite. Such use is underweight children is inappropriate, because its CNS depressant action can affect learning.
6. Vertigo Cinnarizine is the H1 antihistamine having additional anticholinergic, anti-5-HT, sedative, and vasodilator properties which have been widely used in vertigo. It modulates Ca2+ fluxes and attenuates the vasoconstrictor action of many endogenous mediators. Cinnarizine inhibits vestibular sensory nuclei in the inner ear, suppresses post rotator labyrinthine reflexes, possibly by reducing the stimulated influx of Ca2+ from endolymph into the vestibular sensory cells. Beneficial effects have been reported in Méniére’s disease and other types of vertigo. Side effects are sedation and mild g.i. upset. Dimenhydrinate is another effective antivertigo antihistaminic
Cetirizine side effects-Cetrizine tablet side effects.
Headache
Dry mouth
Gastric irritation
Diarrhea
Mild sedation
Dizziness
Sleepiness
Tiredness
Can cetirizine use for cough?
Yes, It provides symptomatic relief means Reduce irritation in Trachea. There are many effective drugs present for cough.
When should I take cetirizine?
You can take it after a meal. It reduces irritation in your nose, Throat.
How long does it take for cetirizine to work?
It works instantly within half an hour and works for 7 to 10 hours.
Is cetirizine good for the blocked nose?
No, Cetrizine is not for nose blockage. You can take Nasal decongestant for an opening a blocked nose.
