Topical NSAIDs
Topical non steroidal antiinflammatory drugs.
Diclofenac 1% gel : Volini gel, Relaxyl gel, Diclonac gel
Ibuprofen 10% gel : Ribufen gel
Naproxen 10% gel : Naprosyn gel
Ketoprofen 2.5% gel : Rhofenid gel
Flurbiprofen 5% gel : Froben gel
Nimesulide 1% gel : Nimulid trans gel, Zolandin gel, Nimegesic t gel
Piroxicam 0.5% gel : Dolonex gel, Movon gel, Pirox gel, Minicam gel
Questions answered below -
topical nsaids otc?
topical nsaids for osteoarthritis?
topical nsaids side effects?
topical nsaids list?
voltaren gel?
topical nsaid cream?
topical nsaids for eyes?
are topical nsaids effective?
What are some topical NSAIDs?
Are there any OTC topical NSAIDs?
What is the best anti inflammatory cream to use?
Are topical NSAIDs effective?
Tropical NSAIDs have been marketed in topical formulation mostly (as gels) for application over painful muscles or joints. these preparations are being used for osteoarthritis, sprains, sports injuries, tenosynovitis, backache, Spondylitis, and other forms of soft tissue rheumatism.
It is presumed that the drug would penetrate to the subjecent tissues attending high concentrations in the affected tissues, while maintaining low blood levels. consequently, the g.i. and other systemic adverse effects would be minimised and first pass metabolism would also be avoided.
while there is no doubt about their safety, doubt has been raised about their actual efficacy over and above a strong placebo effect of local application, messaging and that is due to presence of Counter irritant like methanol, methyl salicylate.
Often, they are used in addition to oral and NSAID medication and guidelines of several professional bodies recommend their use in mild to moderate osteoarthritis of knee and hand as initial or adjunctive therapy.
Measurement of drug concentration attend in tissue underline the site of application as well as concurrent blood levels has shown that systemic absorption from topical nonsteroidal anti-inflammatory drugs preparation is slow, taking 10 times longer time to attain peak concentration compared to oral dosing.
Highest blood levels remain below 15% of the same dose given orally. This is consistent with their lack of systemic toxicity. Local concentrations are up to a depth of 4-6 mm. i.e in dermis. but at 25mm depth in muscles, the concentration is low and really the same as in blood. Marked variation has been noted in the concentration attend in muscles and joints depending on the type of formulation depth and distance from the site of application as well as among different individuals.
Better responses have generally been obtained in short lasting musculoskeletal pain. clinical trials in osteoarthritis of knee have generally rated topical formulations of nonsteroidal anti-inflammatory drugs.
