NSAIDs :Machanis of action,side effects
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| NSAIDs |
nsaids meaning - Non steroidal antiinflammatory drugs
Classification of Non steroidal antiinflammatory drugs -
types of nsaids-
Non selective COX inhibitors (Traditional NSAIDs)
Salicylates - Aspirin
Acetic acid derivative - Ketorolac Indomaethacin Nebumatone
Enolic acid derivative- Piroxicam , Tenoxicam
Propionic acid derivative - Ibuprofen, Flurbiprofen, Ketoprofen, Naproxen
Fenamate-
Mephanamic acid
Pyrazolone derivative -
Phenyl butazone,Oxyphenbutaxone
Selective COX-2 inhibitor -
Etoricoxib
Celecoxib
Parecoxib
Preferential COX-2 inhibitor -
Acelofenac
Nimesulide
Meloxicam
Etodolac
Antipyretic-Analgesic with poor Antiinflammatory action -
Para-aminophenol derivative :
Paracetamol(Acetaminphen)
Pyrazolone derivative :
Metamizol(Dipyrone),Propiphenazone
Benzoxazocine derivative :
Nefopam
Mechanism of action of NSAIDs
Prostaglandin synthesis inhibition
Prostaglandin, prostacyclin(PG I2) and Thromboxane a2(TXA2) are produced from arachidonic acid by the enzyme cyclooxygenase which exist in a constitutive (COX-1) and an inducible (COX-2) isoform,the former serves physiological housekeeping function,while the latter normally present in minute quantities,is induced by cytokines and other signal molecules at the site of inflammation -->generation of PGs locally which mediate many of the inflammatory changes. However, COX-2 is constitutivaly present at some sites in brain, in juxtaglomerular cells and in foetus : It may serve physiological role at these sites. Most NSAIDs inhibit COX-1 and COX-2 nonselectivaly, but now some selective COX-2 inhibitors have been produced. Features of non selective COX1COX2 inhibitors(traditional NSAIDs) and selective COX-2 inhibitors.It acts as Analgesic, antipyretic and antiinflammatory.
nsaids side effects
Gastric pain
Mucosal erosion
Peptic ulcer
Pregnancy - NSAID in late pregnacy has been found to promote premature closure of ductus in some cases.
Headache
Nausea
NSAIDs affect kidney
NSAIDs uses
Analgesic(Pain killer)
Antipyretic(Fever)
Antiinflammatory
Other questions -
Which drugs are NSAIDs?
Mentioned above(Non steroidal antiinflammatory drugs)
Selective COX-2 inhibitor -
Etoricoxib
Celecoxib
Parecoxib
Non selective COX inhibitors (Traditional NSAIDs)
Salicylates - Aspirin
Acetic acid derivative - Ketorolac Indomaethacin Nebumatone
Enolic acid derivative- Piroxicam , Tenoxicam
Propionic acid derivative - Ibuprofen, Flurbiprofen, Ketoprofen, Naproxen
Fenamate-
Mephanamic acid
Pyrazolone derivative -
Phenyl butazone,Oxyphenbutaxone
Preferential COX-2 inhibitor -
Diclofenac
Acelofenac
Nimesulide
Meloxicam
Etodolac
Antipyretic-Analgesic with poor Antiinflammatory action -
Para-aminophenol derivative :
Paracetamol(Acetaminphen)
Pyrazolone derivative :
Metamizol(Dipyrone),Propiphenazone
Benzoxazocine derivative :
Nefopam
What are some common NSAIDs?
Paracetamol,Diclofenac ,Acelofenac
Is paracetamol an Nsaid?
Yes
